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Flora Restore - Probiotic and Intestinal Support

Flora Restore - Probiotic and Intestinal Support
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?The goal of supporting healthy microbes in the gut is to repopulate the gut with new and diverse permanent residents. Most probiotics, while helpful, don't colonize or support the growth of new healthy microbes.

Flora Restore is a heat-stable, clinically researched, four-strain probiotic totaling 30 billion CFU per capsule. While few probiotics have the ability to survive the elements of the human digestive tract (stomach acid, bile secretions and pancreatic enzymes), even fewer have been shown to adhere to the gut wall and proliferate on their own unless they continue to be ingested regularly. The beneficial bacteria in Flora Restore, however, have been shown to survive the digestive tract, adhere to the gut walls and proliferate new and permanent residents in the gut. This encourages your gut to continue to do the job on its own.

Suggested Use: Take one capsule daily with water with meals, or as directed by your healthcare practitioner.

Package Contains:
30 capsules

Ingredients: Bifidobacterium lactis HN019 (15 billion CFU), proprietary blend: Lactobacillus acidophilus LA-14, Lactobacillus plantarum LP-115, Bifidobacterium longum BI-05 (15 billion CFU).

The Science

Supplementation with probiotics has many mechanisms of action that benefit health, including but not limited to: (1) supporting metabolic activity, such as the production of short-chain fatty acids and vitamins, nutrient absorption, and digestion of lactose; (2) adhering to intestinal epithelial cells to help maintain a healthy balance of organisms in the intestinal tract; (3) helping to establish populations of good bacteria after disruption in balance; (4) supporting immune function; (5) promoting intestinal epithelial cell survival; (6) supporting healthy bowel function; and (7) degrading oxalates.[1-8]

Common challenges associated with probiotic supplementation include maintaining stability of the organisms during distribution and shelf life and, once ingested, survival of the organisms as they travel through the digestive tract so that they reach the target tissue (the intestines) alive. To help ensure stability, LifeSpapackages the Flora Restore capsules in sealed, nitrogen-purged aluminum blister packs to serve as protection from factors proven to compromise the stability of probiotics, such as heat, moisture, and oxygen. Because of this, Flora Restore does not have to be refrigerated. Careful selection of organisms is another way LifeSpahelps ensure stability and survival through the digestive tract. To further support resistance to low pH and encourage the delivery of microorganisms to the small intestines, LifeSpaemploys DRcaps gastro-resistant capsules to house the probiotics. These specially designed, innovative capsules help slow exposure of actives to stomach acid to promote a more targeted release.

Probiotic Strains

Bifidobacterium lactis HN019: Researchers have identified Bifidobacterium lactis HN019 as having the best probiotic potential among more than 2,000 strains. Its adherence in high numbers to cultured intestinal epithelial cells contributes to its ability to modulate immunity. Preservation or restoration of healthy intestinal microbiota by this strain has been demonstrated. In addition, studies have shown significant increases of other good gut bacteria such as bifidobacteria and lactobacilli in the presence of this strain. *

Lactobacillus acidophilus La-14: This common inhabitant of the human mouth, intestinal tract, and vagina has diverse health benefits. In vitro studies indicate excellent adhesion to human epithelial cell lines, limiting the ability of enteric pathogens to colonize. Studies have also shown that this strain may inhibit detrimental bacterial strains and re-establish the population of beneficial flora in the intestinal tract.  L. acidophilus La-14 has been demonstrated to support specific immunity in humans.*

Lactobacillus plantarum Lp-115: Commonly found in fermented foods like sauerkraut and fermented olives, L. plantarum is another probiotic that has been shown to safely transit the gastrointestinal tract and adhere to the gut wall. Some studies have indicated that a significant percentage of the population of western cultures are deficient in this important strain.  

Bifidobacterium longum B1-05): This probiotic strain is well suited to the intestinal environment. It is sensitive to vancomycin.*

*Children and pregnant or lactating women should consult their healthcare practitioner prior to use.

*This product does not contain wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or preservatives.


1. Vanderpool C, Yan F, Polk DB. Inflamm Bowel Dis. 2008 Nov;14(11):1585-96. [PMID: 18623173]

2. Abratt VR, Reid SJ. Adv Appl Microbiol. 2010;72:63-87. [PMID: 20602988]

3. Masood MI, Qadir MI, Shirazi JH, et al. Crit Rev Microbiol. 2011 Feb;37(1):91-98. [PMID: 21162695]

4. Turroni S, Vitali B, Bendazzoli C, et al. J Appl Microbiol. 2007 Nov;103(5):1600-09. [PMID: 17953571]

5. Shu Q, Lin H, Rutherfurd KJ, et al. Microbiol Immunol. 2000;44(4):213-22. [PMID: 10832963]

6. Gopal P, et al. Nutr. Res. 2003;23:1313-28. http://www.daniscosupplements.com/clinical-study-bibliography.html. Accessed June 24, 2011.

7. Danisco. Clinical study bibliography & abstracts. HOWARU Bifido – Bif. lactis HN019. http://www.daniscosupplements.com/clinical-study-bibliography.html. Accessed June 24, 2011.

8. Waller PA, Gopal PK, Leyer GJ, et al. Scand J Gastroenterol. 2011 Sep;46(9):1057-64. [PMID: 21663486]

9. Sazawal S, Dhingra U, Hiremath G, et al. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):341-46. [PMID: 20601905]

10. Ahmed M, Prasad J, Gill H, et al. J Nutr Health Aging. 2007 Jan-Feb;11(1):26-31. [ 17315077]

11. Greene JD, Klaenhammer TR. Appl Environ Microbiol. 1994 Dec;60(12):4487-94. [PMID: 7811085]

12. Kleeman EG, Klaenhammer TR. J Dairy Sci. 1982 Nov;65(11):2063-69. [PMID: 7153393].

13. Collado MC, Meriluoto J, Salminen S. Lett Appl Microbiol. 2007 Oct;45(4):454-60. [PMID: 17897389]

14. Ding WK, Shah NP. J Food Sci. 2007 Nov;72(9):M446-50. [PMID: 18034741] 

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* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Disclaimer: The entire contents of this website are based upon the opinions of John Douillard. They are not intended to replace a one-on-one relationship with a qualified health care professional, and they are not intended as medical advice. They are intended as a sharing of knowledge and information from the research and experience of John Douillard and his community. John Douillard encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.