Restore is a heat-stable, clinically researched, four-strain probiotic totaling
30 billion CFU† per capsule. While few probiotics have the ability to
survive the elements of the human digestive tract (stomach acid, bile
secretions and pancreatic enzymes), even fewer have been shown to adhere to the
gut wall and proliferate on their own unless they continue to be ingested regularly. The
beneficial bacteria in Flora Restore, however, have been shown to survive the digestive
tract, adhere to the gut walls and proliferate.
Suggested Use: Take one
capsule daily with water with meals, or as directed by your healthcare practitioner.
Bottle Contains: 30 capsules
HN019 (15 billion CFU), proprietary blend: Lactobacillus acidophilus LA-14,
Lactobacillus plantarum LP-115, Bifidobacterium longum BI-05 (15 billion CFU).
probiotics has many mechanisms of action that benefit health, including but not
limited to: (1) supporting metabolic activity, such as the production of
short-chain fatty acids and vitamins, nutrient absorption, and digestion of
lactose; (2) adhering to intestinal epithelial cells to help maintain a healthy
balance of organisms in the intestinal tract; (3) helping to establish
populations of good bacteria after disruption in balance; (4) supporting immune
function; (5) promoting intestinal epithelial cell survival; (6) supporting
healthy bowel function; and (7) degrading oxalates.[1-8]
Common challenges associated with probiotic
supplementation include maintaining stability of the organisms during distribution
and shelf life and, once ingested, survival of the organisms as they
travel through the digestive tract so that they reach the target tissue
(the intestines) alive. To help ensure stability, LifeSpa™ packages
the Flora Restore capsules in sealed, nitrogen-purged aluminum blister packs to
serve as protection from factors proven to compromise the stability of probiotics,
such as heat, moisture, and oxygen. Because of this, Flora Restore does not have to be refrigerated. Careful selection of organisms is another
way LifeSpa™ helps ensure stability and survival through the digestive tract. To further support resistance to low pH and
encourage the delivery of microorganisms to the small intestines, LifeSpa™ employs
DRcaps™ gastro-resistant capsules to house the probiotics. These
specially designed, innovative capsules help slow exposure of actives to
stomach acid to promote a more targeted release.
Bifidobacterium lactis HN019: Researchers have identified Bifidobacterium
lactis HN019 as having the best probiotic potential among more than 2,000
strains. Its adherence in high numbers to cultured intestinal epithelial cells
contributes to its ability to modulate immunity. Preservation or restoration of
healthy intestinal microbiota by this strain has been demonstrated. In
addition, studies have shown significant increases of other good gut bacteria
such as bifidobacteria and lactobacilli in the presence of this strain. *
Lactobacillus acidophilus La-14: This common inhabitant of the
human mouth, intestinal tract, and vagina has diverse health benefits. In vitro
studies indicate excellent adhesion to human epithelial cell lines, limiting
the ability of enteric pathogens to colonize. Studies have also shown that this
strain may inhibit detrimental bacterial strains and re-establish the
population of beneficial flora in the intestinal tract. L. acidophilus
La-14 has been demonstrated to support specific immunity in humans.*
Lactobacillus plantarum Lp-115: Commonly found in fermented
foods like sauerkraut and fermented olives, L. plantarum is another probiotic
that has been shown to safely transit the gastrointestinal tract and adhere to
the gut wall. Some studies have indicated that a significant percentage of the
population of western cultures are deficient in this important strain.
Bifidobacterium longum B1-05): This probiotic strain is well
suited to the intestinal environment. It is sensitive to vancomycin.*
*Children and pregnant or lactating women
should consult their healthcare practitioner prior to use.
*This product does not contain wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or preservatives.
1. Vanderpool C, Yan F, Polk DB. Inflamm
Bowel Dis. 2008 Nov;14(11):1585-96. [PMID: 18623173]
2. Abratt VR, Reid SJ. Adv Appl Microbiol.
2010;72:63-87. [PMID: 20602988]
3. Masood MI, Qadir MI, Shirazi JH, et al. Crit Rev Microbiol. 2011
Feb;37(1):91-98. [PMID: 21162695]
4. Turroni S, Vitali B, Bendazzoli C, et al. J Appl Microbiol.
2007 Nov;103(5):1600-09. [PMID: 17953571]
5. Shu Q, Lin H, Rutherfurd KJ, et al. Microbiol Immunol. 2000;44(4):213-22. [PMID: 10832963]
6. Gopal P, et al. Nutr. Res. 2003;23:1313-28.
June 24, 2011.
7. Danisco. Clinical study bibliography & abstracts. HOWARU
Bifido – Bif. lactis HN019.
June 24, 2011.
8. Waller PA, Gopal PK, Leyer GJ, et al. Scand J Gastroenterol. 2011
Sep;46(9):1057-64. [PMID: 21663486]
9. Sazawal S, Dhingra U, Hiremath G, et al. J Pediatr
Gastroenterol Nutr. 2010 Sep;51(3):341-46. [PMID: 20601905]
10. Ahmed M, Prasad J, Gill H, et al. J Nutr Health Aging. 2007
Jan-Feb;11(1):26-31. [ 17315077]
11. Greene JD, Klaenhammer TR. Appl Environ Microbiol. 1994
Dec;60(12):4487-94. [PMID: 7811085]
12. Kleeman EG, Klaenhammer TR. J Dairy Sci. 1982 Nov;65(11):2063-69.
13. Collado MC, Meriluoto J, Salminen S. Lett
Appl Microbiol. 2007 Oct;45(4):454-60. [PMID: 17897389]
14. Ding WK, Shah NP. J Food Sci.
2007 Nov;72(9):M446-50. [PMID: 18034741]